TransgenicDB (originally named Transgenic Rodent Assay Information Database, TRAID) is a relational database that incorporates data from studies published to date and unpublished data contributed by several members of the International Workshops on Genotoxicity Testing (IWGT) working group. We have used the TrannsgenicDB to analyse trends in the data and to extract information regarding several key parameters of test performance.
The core is an experimental data table that contains details of 3186 experimental records identified in the literature as well as several complete but not yet published experimental records that have been contributed by members of the IWGT working group. The experimental records contained in the TransgenicDB consist of comparisons between a treatment and a control group; data are not included if the study is limited to an examination of spontaneous mutation or DNA sequence analysis.
Information for the genotoxicity and carcinogenicity data table was derived from the Gene-Tox and Chemical Carcinogenesis Research Information System databases (http://toxnet.nlm.nih.gov), the Genetic Activity Profiles database (Waters et al., 1991) and the published scientific literature.
Centre for NanoHealth, Institute of Life Science, Swansea University, UK